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Compounded GLP-1 medications are prepared under 503A pharmacy standards

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In SURMOUNT 5, GI related treatment discontinuation was actually lower with tirzepatide (2.7%) than semaglutide (5.6%), suggesting the additional GIP mechanism may help buffer GI intolerance

Researchers based the potential definitions on criteria such as prior history of cardiovascular disease or higher BMI levels

Misuse or unsupervised use can lead to health complications

The rationale for developing dual MOR/KOR compounds for OUD treatment is based, in part, on the finding that the MOR partial agonist buprenorphine has been used effectively for the treatment of OUD