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However, the authors stated this is not a clinically significant difference

Pharmacokinetics and Tolerability of a Single Dose of Semaglutide, a Human Glucagon-Like Peptide-1 Analog, in Subjects With and Without Renal Impairment

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The ketogenic group preserved fat-free mass and muscle strength significantly better than the comparison group on a standard low-calorie diet

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While these outcomes are based on large clinical trials (STEP 1 and SURMOUNT-1), weight loss should still be approached with realistic expectations, personalized goals, and ongoing support