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139 Although generally well tolerated, meta-analysis of 14 clinical trials suggests that long-acting GLP-1RAs (eg, semaglutide, tirzepatide) are associated with lower rates of gastrointestinal side-effects, particularly nausea and vomiting, compared to short-acting agents (Table 2)

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People lost weight on both diets, but the main reason was this: They were following the advice to eat as many veggies and whole foods as possible and to reduce added sugars and refined flours

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This trifecta makes it highly effective for managing type 2 diabetes and promoting significant weight loss

Recent Findings The results of multiple randomized clinical trials demonstrate that, among patients with type 2 diabetes, GLP1RAs reduce body weight and improve glucose levels and lipid metabolism