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Injection of GLP-1 directly into the central nucleus of the amygdala (CeA) of rats results in CTA (Kinzig et al., 2002) whereas injection into the PVN reduces food intake without eliciting CTA (McMahon and Wellman, 1998)

PubMed, de Graaf, Chris, et al

The median total duration of protection from FDA approval, when accounting for both pre- and post-approval patents and regulatory exclusivities, was 18.3 years (IQR: 16.0-19.4) (Figure 2)

Val8-GLP-1 also protected against A 1-40 -induced impairment of learning and memory, and reduced total tau expression and hyperphosphorylated tau levels (149, 217)

GLP-1 receptor activation appears to normalize this stress response, reducing the anxiety-driven urge to drink

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