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Rodriguez et al., 2025), with those without T2DM exhibiting even higher rates of discontinuation than those with T2DM (Rodriguez et al., 2025)

Rather than full 4 mg or full 8 mg doses, some healthcare providers prescribe intermediate amounts

3.3 Insulin response In the prediabetes group, treatment with linagliptin did not alter fasting and postload serum insulin levels in prediabetes in both the low and high GLP-1 groups ( Table 3 , Figures 3AC )

While semaglutide is not proven to extend lifespan or reverse aging, the study provides early clinical evidence that GLP-1 receptor agonists may influence biological pathways involved in aging and age-related diseases

As such, GLP-1RAs have become the most widely prescribed anti-obesity agents worldwide [8, 9]