glp-1 receptor agonists and sglt2 inhibitors SGLT-2 Agonists: First-Line Therapy for Diabetes With Established Cardiovascular Disease SGLT2 Inhibitors and GLP-1 Receptor

If youve heard about GLP-1 medications like Wegovy, Zepbound,or Saxenda, you know they help people lose weight by reducing appetite and slowing digestion

In crude analyses, GLP-1 receptor agonist use was associated with an increased incidence of suicidality compared with DPP-4 inhibitors (crude incidence rates 3.9 v 1.8 per 1000 person years, respectively

Beyond these metabolic benefits, accumulating evidence indicates that GLP-1RAs exert immunomodulatory effects, including suppression of pro-inflammatory cytokines, enhancement of regulatory T-cell function, and improvements in adipose tissue and gut-derived immune signaling

GLP-1s arent for everyone

By 2030, the global prevalence of obesity is expected to reach one billion

Understanding their distinct mechanisms, clinical evidence bases, and how genetic and biomarker data inform personalized treatment selection helps patients and providers make evidence-based decisions