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According to the authors, some people have anecdotally reported anhedonia-like symptoms after they started taking a GLP-1, but so far, theres been little written about the phenomenon

Research shows that approximately 50% of weight loss returns within one year after stopping GLP-1 medications if no lifestyle modifications are maintained

Canedo JR, Miller ST, Schlundt D, Fadden MK, Sanderson M

GLP-1s help lower your set point by decreasing hunger, increasing satiety, and regulating hormones

[DOI] [PubMed] [Google Scholar] 210.Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, et al

However, distinguishing between normal cold sensitivity and symptoms requiring clinical attention is important