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The observed protective effects are mediated through multiple molecular mechanisms, including enhanced metabolic regulation, direct anti-proliferative actions, and augmented immune surveillance [16, 17]

Comparable to therapy with GLP-1RA, a stepwise dose escalation starting with a low starting dose was associated with a lower rate of gastrointestinal side effects and better tolerability of tirzepatide (67)

doi: 10.2337/db13-1087

Those numbers mean most patients will not develop persistent arrhythmias, but if palpitations are accompanied by chest pain, fainting, or breathlessness, treat them as urgent