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Here, we confirm that neither Epsin nor the cytosolic domains of DSL proteins are required for Notch signaling in C

These findings demonstrate that both basal and agonist-induced GLP-1R phosphorylation are critical for receptor signalling in -cells, revealing a previously unappreciated role for basal phosphorylation in shaping receptor behaviour and establishing a positive link between GLP-1R phosphorylation and -cell signalling competence