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GDF-8 expression levels in follicular fluid and in serum tend to be elevated in PCOS patients, although it is noteworthy that this effect is only observed in obese PCOS patients (289)

Patients taking multiple medications for diabetes, hypertension, or other conditions may experience additive effects that contribute to fatigue

The authors declare no conflict of interest with the Korea Medical Institute

Food and Drug Administration (FDA) and by Health Canada in 2017 for glucose control but has found a significant increase in off-label use for weight management

If fatigue persists despite these interventions, or if it is accompanied by other concerning symptoms, further medical evaluation is warranted to exclude alternative diagnoses

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