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Description
While GLP-1 medications reduce appetite through central and peripheral mechanisms, fiber provides additional satiety through gastric distension and prolonged digestion

JAMA Intern Med 2022;182:513-9.ArticlePubMedPMC 40

The medication is designed with built-in flexibility

Tablets should be kept in the original RYBELSUS bottle with the blue cap whenever the patient is not taking one
The documented label and trial protocol does not use a single fixed dose
Figure 2 Appetite contains a large hedonic component mediated by the central reward system
