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Lower pricing for both the Medicare and consumer cash-pay channel as a result of MFN, as well as patent expiries in jurisdictions including Brazil, Canada and China will "probably lead to a decreasing top line," said Hansen

Additionally, the proportion of exposure variance explained by instrumental variables was evaluated using R 2 , computed as R 2 = 2 EAF (1 EAF) 2 , where EAF denotes the effect allele frequency of the exposure

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