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Moreover, the once-weekly administration of tirzepatide not only improves patient compliance but also simplifies the treatment regimen, making it more advantageous for long-term treatment (as seen in SURPASS-2)

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In parallel, the weight loss on Zepbound was also markedly greater: 20.2% versus 13.7%

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Zada G, Tirosh A, Kaiser UB, Laws ER, Woodmansee WW

In a post hoc analysis of the SUMMIT trial, the decrease in estimated blood volume seen in participants treated with tirzepatide was significantly correlated with decreased blood pressure, lower microalbuminuria, improved KCCQ-CSS, and greater 6-min walking distance [85]