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However, an exposure-response modeling analysis suggested that an initial deterioration in A1C may be seen when switching from dulaglutide 1.5 mg once weekly or liraglutide 1.2/1.8 mg once daily to the initial recommended 0.25 mg once-weekly dose of subcutaneous semaglutide (62)

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That flexibility matters because tirzepatide tends to produce stronger average weight loss for some patients, while others prefer semaglutide or want to avoid injections entirely