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The therapeutic landscape for obesity management is rapidly evolving

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[5] [6] The GIP receptor component is thought to contribute to metabolic and appetite-related effects, whilst glucagon receptor activation may increase energy expenditure and promote fat breakdown (lipolysis) in the liver and adipose tissue

4 The ACC document additionally provided a series of opportunities in which clinicians may consider starting a GLP-1 RA or an SGLT-2 inhibitor with demonstrated cardiovascular benefit 4 : In a patient with T2D and ASCVD

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