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These covariates included demographics (age, gender [male, female, unknown], race [Black or African American, White, Asian], ethnicity [Hispanic or Latino, Not Hispanic or Latino, unknown], and marital status), socioeconomic determinants of health (SDOHs) including education, employment, environmental exposure, and housing, problems related to lifestyle, cancer, diabetes severity indicators (e.g., obesity, complications like nephropathy, liver, neuropathy, heart disease), some conditions known to be associated with constipation or intestinal obstruction (e.g., diseases of intestines, diseases of appendix), and prior prescription of medicines associated with diabetes, decreased intestinal motility, or constipation [15, 16, 27,28,29,30]

In fact, just seven out of the 29 studies investigated the consummatory phase of reward (Bogdanov et al., 2020

doi: 10.3233/JAD-190237 [DOI] [PubMed] [Google Scholar] 142

3 The treatment complexities The treatment of cancer in individuals who are both obese as well as diabetic poses significant challenges due to the intricate interplay between these conditions, and addressing these challenges involves navigating a complex landscape (Fig