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Food and Drug Administration placed a box warning on GLP-1 medications due to this risk in rodents
Gases: Small molecular gases like oxygen and carbon dioxide can freely cross the BBB to meet the brains oxygen demand
Most patients experience brief discomfort during or immediately after injection that resolves within minutes to hours

doi: 10.1111/dme.14953 14 BurtonPSmitHJLightowlerHJ

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Retatrutide's glucagon receptor agonism adds an additional layer of heart rate elevation beyond what GLP-1 alone would produce