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Meanwhile, orforglipron demonstrated significant weight loss efficacy [8] consistent with injectable GLP-1 medicines

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In clinical practice, drug selection should therefore prioritize factors such as tolerability, safety profile, adherence, cost, and patient preference rather than expecting major differences in cardiovascular efficacy.

Additionally, the nominal group technique was used to gather insights from medical experts from different areas regarding the combined therapys daily clinical use, concerns, and limitations

Secondary outcomes included time below and above the therapeutic range and INR variability