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Despite the extensive evidence supporting the beneficial effects of GLP-1RAs on the central nervous system (CNS), emerging studies have raised concerns about potential adverse effects

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For people concerned about the relatively short track record of newer agents like tirzepatide or retatrutide, liraglutide offers peace of mind backed by years of real-world outcomes data across millions of patients

[DOI] [PubMed] [Google Scholar] 25.Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM

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This is the point where the bacterial strains should be well established, metabolite production should be consistent, and the downstream effects on GLP-1 should be at their peak