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Given the heterogeneity of the included evidencespanning case reports, pharmacovigilance analyses, and observational cohortsthis review is framed primarily as a signal-detection and evidence-mapping exercise rather than a causal-inference analysis

Roche reported positive Phase II topline data showing that its once-weekly dual glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist CT-388 achieved substantial, sustained, and dose-dependent weight loss through 48 weeks

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What I'm watching: The Alzheimer's Association listed GLP-1 research as a top 10 development to watch in 2026

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Understanding these differences, supported by genetic predisposition data, can help guide more informed conversations with healthcare providers about