insurance coverage for glp 1 Weight loss drugs' high costs prompt Cigna to cut employee health plan GLP-1 Insurance - Why Employers

ScienceDaily.com slapped this headline on it: The Guardian reported: Healthline.com reported: Using relative risk reduction figures almost always makes the benefit seem larger than it really is, and thereby misleads the general public

Preclinical studies have identified that GLP-1 analogs such as exendin-4 and GLP-1RAs have direct anti-atherosclerotic and anti-inflammatory effects that may contribute to their cardio- and neuroprotective nature.[42] GLP-1RAs can also directly interact with cardiomyocytes, inducing receptor-mediated ischemic conditioning that decreases myocardial infarct size in test animals receiving GLP-1RAs.[43] Similar effects were noted in rodent brains, with liraglutide reducing cerebral infarct volume in rats.[42] Randomized clinical trials (RCTs) also identified that exenatide similarly reduced myocardial infarct size and liraglutide reduced the resulting necrotic area in human patients following a MI.[43] This may account for the reduced need for coronary revascularization in patients on GLP-1RAs.[12] Despite the findings of overall improvements to composite cardiovascular outcomes, GLP-1RAs showed a non-significant trend toward reducing MI risk and did not affect rates of hospitalization for unstable angina in patients with diabetes.[12] These agents tend to have a stronger effect on stroke reduction in such patients, highlighting the complexity and variability of cardiovascular disease and its sequelae

Blue Cross and Blue Shield of Kansas estimates that the cost to employers for adding GLP-1 weight loss coverage to their plan would result in an approximate 30 percent increase in drug coverage premiums

Generic liraglutide is the first once-daily generic GLP-1 injectable approved to treat Type 2 diabetes in patients 10 and older, alongside diet and exercise

For severe nausea, eat smaller portions more slowly, avoid lying down after eating, limit high-fat and spicy foods, try ginger tea or crackers, and stay hydrated

and GSBR-1290, now in early Phase IIa evaluation