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Therefore, early phase clinical trials must carefully assess safety and tolerability

2 Methods 2.1 Eligibility criteria This meta-analysis was registered prospectively in PROSPERO (CRD420251147337) and was carried out following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) recommendations

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"If any appeal that we make is unsuccessful, there are other treatments that we can use," he says for example drugs like Contrave or a cheaper combination of generic naltrexone and bupropion