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In the second case, a 40-year-old woman with a history of depression reported worsening mood symptoms, including fatigue, cognitive slowing, and suicidal thoughts, approximately two months after beginning semaglutide for diabetes management
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Surprisingly, this effect was avoided by the administration of exendin [9-39], an antagonist of GLP-1
Motor and cognitive advantages persist 12 months after exenatide exposure in Parkinson's disease

[29, 30, 31] Risk factors: Diabetes (especially in combination with SGLT2 inhibitors use) Reduced oral intake and severe GI symptoms Dehydration Presentation: Nausea, vomiting, abdominal pain Anion gap metabolic acidosis Elevated ketones Normal or mildly elevated glucose Key point: EDKA has not been observed in non-diabetic patients in large cohort data

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