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Compounded versus pharmaceutical versions The source of your medication matters
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doi: 10.1371/journal.pone.0135233

This may be explained by a relatively low trial drug exposure (76%) compared to other CVOTs, and that the trial had no run-in period and, therefore, had one of the highest discontinuation rates

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This hypothesis has been confirmed in clinical trials including hypertensive patients that demonstrated an improved blood pressure control (30, 31) and reduction of cardiovascular events (31) when anti-hypertensive drugs have been administered at bedtime
