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The need to inject the drug every week, however, can be a deterrent for the needle-phobic

In the Phase 2 trial, the most common adverse events were gastrointestinal: nausea (up to 25.6% at higher doses), diarrhea (up to 22.0%), vomiting (up to 12.2%), and constipation (up to 11.0%)

It does mean the evidence base for a specific compounded preparation is different from the evidence base for an FDA-approved finished drug product

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They set up a policy where compounders could work around FDA approval guidelines in cases of shortages." But right now, there is no shortage of GLP-1 medications, and because companies like Eli Lilly and Novo Nordisk have patents, patients are likely years away from FDA-approved generics

Instead of mimicking GLP-1, diet and lifestyle interventions help the body produce its own hormone