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We present a detailed picture showing that epithelial-to-mesenchymal transition, cancer metabolic reprogramming, alterations in important signalling pathways, epigenetic aberrations and the tumour microenvironment are crucial drivers of PTC metastasis

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Treatment selection should be individualized based on clinical priorities and patient characteristics

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Successful weight loss and maintenance comes only with continued reinforcement and adherence to healthy lifestyle habits.

In addition, there will be a $350 million up-front payment as Abbvie takes over the reins of GUB-014295 (referred to as Gubamy), a long-acting analog of the satiety hormone amylin, currently in phase I development.