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Interestingly, normal physiological levels of GLP-1 do not significantly stimulate metabolism, but prolonged elevation from receptor agonists can have a meaningful effect

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Hannon J, Hoyer D

Risk of amputation with canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study

2 Glucagon-like peptide-1 receptor (GLP-1R) agonists have shown remarkable therapeutic effects for type 2 diabetes mellitus (T2DM)

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