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It remains unclear whether there is a relationship between the central actions of peripheral GLP-1 and the GLP-1-producing neurons in the brain stem, but it is clear that one of the most important actions of peripheral GLP-1 is to regulate food intake in agreement with its ileal brake function

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Footnotes Conflict of Interest The author declares no conflict of interest

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Finally, the neurobiological heterogeneity across SUDs underscores the importance of substance-specific clinical trials tailored to distinct mechanisms and outcome measures