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The primary endpoint was the 3-point major adverse cardiovascular events (3P-MACE)

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The incidence of MBSH ranged significantly across different diagnostic methods: 2.666.4% (self-report), 6.661.8% (oral glucose tolerance test), 29.478.6% (mixed-meal tolerance test), and 5075% (continuous glucose monitoring)

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There is substantial evidence suggesting that AMPK is dysregulated in animals and humans with metabolic syndrome or T2D, and that AMPK activation (physiological or pharmacological) can improve insulin sensitivity and metabolic health

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