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It avoids first-pass liver metabolism, which means lower risk of blood clots and a better lipid profile compared to oral estrogen

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It is produced through chemical peptide synthesis methods in controlled manufacturing environments

Vitamin B12 (asMethylcobalamin) 50 mcg

Patients with diarrhea-predominant IBS (IBS-D) may theoretically tolerate these medications better, as the slowed gut motility could reduce bowel urgency and frequency
