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Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders

Finally, although higher circulating levels of lipase and amylase were reported in patients on GLP-1 RA therapy in many trials, the increases were rarely higher than three or five-fold the upper limit of normal (ULN), respectively [9,10,11,12,13,14,15,16,17], returned to normal levels after medication withdrawn, and were poor predictors of AP [54]

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Sleep quality changes during treatment While the long-term trajectory is typically positive for sleep, the short-term experience can be more variable

33 , 34 , 42 However, longer-term safety data, particularly in high-risk subgroups, are needed to clarify whether sustained heart rate elevation modifies cardiovascular risk over time