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Semaglutide is highly effective, tirzepatide is superior with dual agonism, and retatrutide, with its triple-action mechanism, currently offers the greatest weight loss and best tolerability seen in pharmacotherapy

Quantification was performed using Image Lab software version 6.1 (Bio-Rad), using total protein normalization 20

Patients should be educated on recognising hypoglycaemia symptoms (tremor, sweating, confusion, palpitations) and have a management plan in place, including access to fast-acting carbohydrates

Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation

Retatrutide does not yet have dedicated cardiovascular outcome trial data

It may take 6 to 8 weeks to see full improvements in depressed mood and lack of interest