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Their repurposing aligns with precision medicine paradigms, enabling tailored therapies for patients with comorbid conditions like obesity, diabetes, and chronic pain

Repeated cycles of initiation, interruption and re-initiation of these drugs might induce body weight and HbA 1c fluctuations two risk factors for cardiovascular and microvascular events

doi: 10.1007/s40618-020-01351-0

Oral administration of corn zein hydrolysate stimulates GLP-1 and GIP secretion and improves glucose tolerance in male normal rats and Goto-Kakizaki rats

Abstract Glucagon-like peptide-1 (GLP-1) is a hormone involved in glucose homeostasis and satiety regulation

The carbonyl group of the linker was discovered to form a hydrogen bond with Asn710, whereas the primary or secondary -amino group forms salt bridges with Glu205 and Glu206