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Erratum in: N Engl J Med

The three main types of macrovascular complications seen frequently in diabetes are coronary artery disease, cerebrovascular disease, and peripheral arterial disease

The pens should always be kept in their original packaging to protect them from light exposure, which can also affect stability over time

Or is it something more serious, like dementia

Using an estimated effect size of a 15% difference in the proportion of participants achieving 10% weight loss between groups, with an expected 30% of engaged participants and 15% of nonengaged participants achieving this outcome, a minimum of 118 participants per group was calculated to provide 80% power at a 5% significance level