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JANUVIA WORKs in 2 ways with a glucose-dependent mechanism of actION increasing insulin production and reducing hepatic glucose production DPP-4 Inhibition Oral glucose stimulates release of incretins (GLP-1 and GIP) DPP-4 rapidly degrades incretins JANUVIA inhibits DPP-4 to increase active incretins

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adipocytes) to take up glucose when stimulated by insulin

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Int J Mol Sci 2021;22:1680.ArticlePubMedPMC 6

If youre under-replaced and undertreated before starting treatment, you may feel like the new medication is not working when the real issue is that the thyroid itself still needs adjustment