retatrutide mechanism triple agonist glp-1 gip glucagon How Does Work? Explained Beyond GLP-1: Retatrutide's triple-agonist mechanism

GUT MICROBIOTA AND CHRONIC KIDNEY DISEASE A recent study investigated the complex relationship between gut microbiota, uremic toxins (UTs), diet, and the progression of chronic kidney disease (CKD) in non-dialysis patients [16]

The GLP-1 effect on MedTech

On one hand, the cardiovascular protection afforded by SGLT2is seems to result from their beneficial hemodynamic effects, including improvement in ventricular preload (secondary to natriuresis and osmotic diuresis) and afterload (through blood pressure reduction), but also from improvement of cardiac metabolism (through the switch from utilization of glucose to ketones), inhibition of the myocardial Na + /H + exchanger, reduction of cardiac fibrosis and necrosis, reduction of proinflammatory adipokines derived from epicardial and perivascular fat, and stimulation of erythropoiesis (which can facilitate the release of oxygen to ischemic tissues) [1, 4, 14,15,16]

They minimize systemic inflammation by many mechanisms: direct suppression of pro-inflammatory cytokine synthesis (TNF-, IL-6, IL-1), augmentation of anti-inflammatory mediators (IL-10, adiponectin), and alteration of immune cell morphologies

"We are not saying that semaglutide reverses aging or makes people younger," said Corley

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