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While clinical trials are ongoing, a study published in Alzheimers & Dementia in October 2024 found that people with Type 2 diabetes who used semaglutide (the active ingredient in Ozempic, Wegovy, and Rybelsus) had a lower risk of a first-time diagnosis of Alzheimers disease, compared to people who used insulin, other GLP-1s, or other diabetes medicines

Additional research is necessary to examine fracture reduction independent of weight loss. This research may also mainly pave the way for more research, rather than giving definite answers

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Retatrutide is a triple receptor agonist that adds GIP and glucagon activation on top and the early trial results have genuinely surprised the research community

We conclude that mig-6L interacts synergistically with glp-1 during embryonic and larval development, in addition to within the context of GSC niche signalling, and acts to restrict glp-1/Notch signalling