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Patients typically begin noticing that they feel hungrier between meals, that portions that previously satisfied them no longer feel filling, and that food cravings particularly for higher-calorie foods begin to increase

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Days 45: Side Effects May Become More Noticeable For patients who develop gastrointestinal symptoms, this is often when they become most noticeable

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The comparison between retatrutide and tirzepatide reveals this as more than a marginal improvement