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No significant drug interactions have been identified between GLP-1 receptor agonists and standard autoimmune medications including methotrexate, biologics (TNF inhibitors, IL-6 inhibitors), JAK inhibitors, or hydroxychloroquine

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Collectively, this indicates a role for CNS GLP-1R populations to mediate food intake suppression by pharmacologic, and to a lesser degree physiologic, GLP-1R agonism

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Additionally, there may be potential risks of pancreatitis

Some of the GLP-1s approved to treat T2D, such as Ozempic, are also widely known to be used for weight loss