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But we know that for patients with HFpEF and obesity, a maximum of 10% body weight reduction can be achieved through both diet and exercise (in the structured and supervised clinical trial setting) but quality of life remains markedly impaired

Some of those taking Ozempic or Wegovy are learning that too much of a good thing is never good.Semaglutide, the medication prescribed under the brand names Ozempic, for treating Type 2 diabetes, and Wegovy, for weight management, works by mimicking the hormone GLP-1, which is released by the gut after eating

GLP-1 short-term side effects include: Nausea Vomiting Diarrhea Constipation Headaches Fatigue Dizziness GLP-1 long-term side effects include: Ongoing and persistent irregular bowel movements Sluggish digestion Changes in gut comfort over time Impact on bone health and density Reduction in muscle mass Nutritional deficiencies Its important to note that long-term GLP-1 medication side effects have not been well-studied

Nearly one in five adults said they have taken a GLP-1 drug at some point, the data also found

This notion implies the presence of an accessory secretory stimulus from the gastrointestinal tract, unrelated to blood glucose levels