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The FLOW trial demonstrated a 27% decrease in heart failure events among T2DM patients with CKD thus confirming their effectiveness in HF management [58]

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These results were more difficult to explain as the mouse plasma half-life of 11 is prolonged (31 min) and the potency (13%) is comparable to 14 (6%), 22 (19%) and 23 (7%)

Within the brain, agonism of GLP-1 could enhance cognitive function and diminish neuroinflammation and potentially provide a protective effect against diseases that are NDs, including Alzheimers disease and Parkinsons disease

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