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Hypothyroid symptoms include unexplained fatigue, cold intolerance, constipation, dry skin, or unintended weight gain despite continued semaglutide use

The published preclinical dosing was IP injection

The diabetic drug oral semaglutide has demonstrated remarkable effects in reducing weight and HbA1c, a gauge of average blood sugar levels over time

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Participants with T2DM also showed improved HbA1c levels and favorable lipid profile changes (Kapitza et al., 2023)

Notably, in the placebo group, greater early weight loss was paradoxically associated with higher subsequent MACE risk, likely reflecting unintentional weight loss or underlying illness