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2 University of Ottawa Heart Institute, Ottawa, Ontario, Canada

doi: 10.1038/s41586-024-07685-6 77 LuZChanSWTuLNganMPRuddJA

Tirzepatide works by targeting both the GLP-1 and GIP (gastric inhibitory polypeptide) hormones, which further regulates appetite and blood sugar

does not provide any tools for tracking medications, making it less suitable for GLP-1 users who need to manage injection schedules and medication effectiveness

Peptide-based drugs often require injection because: They degrade easily outside controlled environments They are too large to cross intact skin barriers Stable blood levels are difficult to maintain via topical application The Johns Hopkins Medicine resource on obesity management reinforces that medically supervised pharmacotherapy is part of comprehensive care rather than a standalone quick fix

however, patients can experience gastrointestinal reactions such as nausea, vomiting, and diarrhea, and long-term injections can result in significant biohazardous waste, as well as an elevated likelihood of complications, including lipoatrophy, inflammation, and the formation of subcutaneous nodules, and infections [88]