glp-1 effect on insulin Frontiers Schematic of action of GLP-1

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Testing during the preconception planning phase allows patients and providers to anticipate metabolic changes and optimize rapid, safe weight management after delivery

In rodent models, activation of the GLP-1 neurons also results in activation of stress responses, including anxiety-like behavior (Maniscalco and Rinaman, 2018)

Physiol Rev (2011) 91:102370

They enhance insulin when glucose is high, dampen glucagon, and slow gastric emptying, which together reduce energy intake