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Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease and is associated with significant cardiovascular morbidity and mortality
Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice

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As a triple receptor agonist targeting the GLP-1, GIP, and glucagon receptors, it represents a structurally advanced tool for investigators working at the intersection of metabolic biochemistry and peptide pharmacology

Rats receiving vagotomy do not reduce food intake in response to peripherally injected GLP-1 indicating that vagal afferent nerves are needed to relay peripheral GLP-1 signals to higher brain regions to regulate feeding (Abbott et al., 2005)
