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Here, the authors report cryo-EM structures of tirzepatide-bound GIPR and GLP-1R, peptide 20-bound GIPR, GLP-1R and GCGR, revealing the molecular basis of their multiplexed pharmacological actions.

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Highly sensitive GLP-1 formulations demand a packaging that preserves stability, ensures precise dosing, and performs seamlessly with delivery devices

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GLP-1 analogs exert several biological activities connected not only with an insulinotropic effect but also with ...