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No significant differences were observed for myocardial infarction, stroke, or revascularization with risk differences of 0.1% (95% CI 1.0 to 0.8%), 0.8% (95% CI 0.2 to 1.7%), and 0.2% (95% CI -0.71.1%), respectively

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Gastrointestinal issues such as nausea, vomiting, diarrhea, and abdominal pain are among the most frequently reported side effects, especially at the start of treatment

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A 2025 meta-analysis in JAMA Psychiatry looked at GLP-1 receptor agonists and mental health outcomes across multiple studies