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By demonstrating protective effects in a ciliopathy model, this study suggests that GLP-1 RAs may confer benefits beyond appetite suppression in patients with genetic obesity syndromes affecting ciliary function, further broadening the mechanistic rationale for targeting this pathway across diverse genetic etiologies of obesity

( F , G ) The expression of TIG-2::mCherry ( F ) and mCherry ( G ) by indicated promoters

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These medications were originally developed to help manage type 2 diabetes, but they are now widely used as part of medically supervised weight management programs

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