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The SURMOUNT-MMO trial (ClinicalTrials.gov ID NCT05556512), estimated to be completed in October 2027, is currently studying the role of tirzepatide in people with a BMI 27 kg/m 2 without diabetes, with a high risk for CVD

doi: 10.1056/NEJMoa1411892 44 WildingJPHBatterhamRLCalannaSDaviesMVan GaalLFLingvayIet al

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GLP-1 medications work by mimicking the actions of your natural GLP-1, binding to cells throughout your body that have GLP-1 receptors, and ultimately lowering blood sugar

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Renal function should be monitored, as severe gastrointestinal adverse effects can lead to dehydration and acute kidney injury, particularly in patients with pre-existing renal impairment