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Meanwhile, both dulaglutide and tirzepatide are manufactured by Eli Lilly

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[10] [11] Based on data from retatrutide clinical trials (NEJM, 2023) and experience with similar approved agents, patients may experience: Redness, swelling, or itching at the injection site, which typically resolves within a few hours to days Bruising or mild pain immediately following injection Nodules or localised reactions beneath the skin, which may occur with repeated injections at the same site These reactions are generally mild and self-limiting

The SmPC specifically advises that the dose of insulin or sulphonylureas may need to be reduced when initiating semaglutide treatment

JAMA , 325 (14), 1414-1425